Half of GI Cancer Patients Run Out of Options

When chemotherapy fails, immunotherapy does not respond, and targeted therapies do not apply, patients are left without a path forward. BiPER Therapeutics is developing an oral drug, selected by blood test, to treat that gap directly.

What’s UpNext: Signals from the Global Startup Circuit

The F1 Circuit of the Startup Ecosystem. Tracking founders, momentum, and signals as they emerge.

Aquaplaning Has Existed Since the First Car. This Turin Founder Decided to Eliminate It.

Aquaplaning has caused accidents since the first cars drove on wet roads. Giovanni Blandina founded EasyRain in Turin to become the first company to actively restore grip, not just detect its loss.

What’s UpNext: Signals from the Global Startup Circuit

The F1 Circuit of the Startup Ecosystem. Tracking founders, momentum, and signals as they emerge.

Every Surgery Produces Enough Data to Predict Complications. Why Is Almost None of It Being Used?

Every year, 60 million patients suffer anesthesia complications that current monitoring cannot anticipate. Eva Gubern and Pedro Gambús built Predictheon to change that, starting with 30 years of mathematical modelling and a proprietary patient database nobody else has.

Most Great Athletes Never Get Discovered. SEE Is Changing the Odds

Abdelrahman Ghareeb dislocated his knee in 2014 and spent the next decade asking why nobody saw it coming. The Egyptian founder built SEE, an AI platform that turns any phone camera into an objective movement assessor, to give every athlete the data that only professionals have ever had.

Why 85% of Mental Health Patients Don't Improve, and What Braive Is Doing About It

Hermine Bonde Jahren watched her husband's psychology clinic struggle with an ever-growing waiting list and realized the access crisis was only half the problem. She built Braive to fix what happens after you get through the door, and it now supports 100,000 patients across the Nordics.

Every Consulting Project Starts From Scratch. Intriq Is Changing That.

Jess Liew spent over a decade watching consulting teams rebuild from zero on every new engagement, manually assembling data before the real work could even begin. She built Intriq to break that cycle, so advisors can skip the groundwork and get straight to the insights their clients actually need.

What’s UpNext: Signals from the Global Startup Circuit

The F1 Circuit of the Startup Ecosystem. Tracking founders, momentum, and signals as they emerge.

Why Retail Media Keeps Failing Smaller Retailers and How Cruxo Is Built to Fix It

Brands and retailers across Central and Eastern Europe have been handed retail media solutions that start three stages ahead of where they actually are. Jakub Spryngl and his co-founders left Procter & Gamble to build Cruxo, the platform that meets them where they are.

GITEX Africa: Sovereign Systems Replace Infrastructure Narratives

GITEX Africa 2026 confirmed that African tech has moved past infrastructure storytelling into deployment at scale. Sovereign digital strategies and cross-border fintech are now live products, not roadmaps.

A Wearable That Finally Tracks Female Hormones in Real Time

Estonian founder Kerli Luks spent years as a doctor watching women navigate hormonal health on incomplete data. Her company Muun Health is building the first continuous hormone monitoring device.